The paper presents a quantitative and qualitative dimensions of congenital heart defect (CHD) research output in India, based on publications data (1335) indexed in Scopus database during 2000-19. CHD research registered 10.0% growth, averaged 7.07 citations per paper, contributed 3.04% share to the global output and constitute 13.48% share of India’s research as international collaborative. CHD research is skewed as top 10 countries account for 83.23% of global output. India ranks as the 10th most productive country in the world. The distribution of CHD research by type of research reveal that Tetralogy of Fallout accounted for the highest share (34.31% share), followed by Aortic Stenosis (30.41%), Atrial Septal Defects (28.16%), Ventricular Septal Defects (26.22%), etc. AIIMS - New Delhi, Amrita Institute of Medical Sciences, Coimbatore and PGIMER - Chandigarh lead the country as the most productive organizations (with 222, 73 and 64 papers). Besides, Amrita Institute of Medical Sciences, Coimbatore (33.88 and 4.79), SCTIMST - Trivandrum (30.73 and 4.35) and Institute of Medical Sciences, BHU, Varanasi (17.20 and 2.43) lead the country as the most impactful organizations in terms of citation per paper and relative citation index. B. Airan, A. Saxena and S. Talwar have been the most productive authors (with 63, 63 and 59 papers) and P. Khairy (16.31 and 2.31), B. Vaidyanathan (14.3 and 2.03) and R.K. Kumar (10.53 and 1.49) have been the most impactful authors. Indian Heart Journal, Annals of Pediatric Cardiology (84 papers) and Annals of Cardiac Anaesian (53 papers) topped the list of most productive journals (with 110, 84 and 53 papers). International Journal of Cardiology (18.62), Catheterization and Cardiovascular Interventions (16.64) and Journal of Cardiothoracic and Vascular Anesthesia (11.65) leads in ranking in terms of citation per paper.