The millennium development goals (MDGs) adopted during the millennium summit in 2000 gave an opportunity to improve the health and overall development. The MDG framework had 8 goals, 21 targets, and 60 indicators. Of these, three are directly related to health and have other interrelated goals and targets that influence health. The year 1990 is baseline, and the targets are to be reached by 2015. India’s progress towards health related MDGs is lagging in some areas, and more attention is needed to states and districts where the indicators are poor. The proportion of underweight children <3 years is around 40%. The under-five and infant mortality rate is 49 and 40/1000 live births in 2013, respectively. The country lags behind the maternal mortality ratio target of 109/100,000 live births. Regarding HIV, malaria, and tuberculosis, trend reversal had been achieved while providing basic sanitation facilities remains a big challenge.