Objective: This study was carried to analyze the self medication pattern in rural areas of Pune. Method: Semi-structured questionnaire was used for collection of data. Information about age, sex, name of the self medication, diagnosis for the use of self medication, source of information about the self medication and adverse effects reported to self medications was collected. Results: NSAIDs (33.33), antibiotics (10.32), vitamins (14.08) and GIT ailment drugs (13.61) are most commonly used as self medication in rural areas. Other drugs that self medicated are: drugs for upper respiratory tract infection, antibiotics, antihypertensives, anticonvulsants and diuretics. Information about the self medication was predominantly obtained from previous prescription of doctors (64.32%) and from chemists (23%). Antibiotics like macrolides, fluoroquinolones, cephalosporins, antihelminthics, and furazolidine were taken as self medication in rural areas. 50% of antibiotics used as self medication was associated with development of ADRs. The adverse effects reported with antibiotics self medication were: vomiting, hyperacidity, gastrointestinal discomfort. 21.13% of persons reported adverse effects with NSAIDs self medication. Adverse effects reported with analgesic use in this study were: hyperacidity, skin rashes, nausea. Conclusions: NSAIDs, antibiotics, vitamins and GIT ailment drugs are commonly self medicated in rural areas of Pune. The self medication of antibiotics is disturbing, as these are liable for drug resistance and severe ADRs and hence should be taken under supervision only. Pharmacists, key person in rural areas, can provide information about adverse effects of self medicated drugs and also can guide about proper precautions to be taken for self medication.